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  Designing sequences that satisfy multiple, often conflicting, objectives is a central challenge in therapeutic and biomolecular engineering. Existing generative frameworks largely operate in continuous spaces with single-objective guidance, while discrete approaches lack guarantees for multi-objective Pareto optimality. We introduce **AReUReDi** (**A**nnealed **Re**ctified **U**pdates for **Re**fining **Di**screte Flows), a discrete optimization algorithm with theoretical guarantees of convergence to the Pareto front. Building on Rectified Discrete Flows (ReDi), AReUReDi combines Tchebycheff scalarization, locally balanced proposals, and annealed Metropolis-Hastings updates to bias sampling toward Pareto-optimal states while preserving distributional invariance. Applied to peptide and SMILES sequence design, AReUReDi simultaneously optimizes up to five therapeutic properties (including affinity, solubility, hemolysis, half-life, and non-fouling) and outperforms both evolutionary and diffusion-based baselines. These results establish AReUReDi as a powerful, sequence-based framework for multi-property biomolecule generation.
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- Check out our paper: ([Chen et al. 2025](https://arxiv.org/abs/2412.17780))
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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  Designing sequences that satisfy multiple, often conflicting, objectives is a central challenge in therapeutic and biomolecular engineering. Existing generative frameworks largely operate in continuous spaces with single-objective guidance, while discrete approaches lack guarantees for multi-objective Pareto optimality. We introduce **AReUReDi** (**A**nnealed **Re**ctified **U**pdates for **Re**fining **Di**screte Flows), a discrete optimization algorithm with theoretical guarantees of convergence to the Pareto front. Building on Rectified Discrete Flows (ReDi), AReUReDi combines Tchebycheff scalarization, locally balanced proposals, and annealed Metropolis-Hastings updates to bias sampling toward Pareto-optimal states while preserving distributional invariance. Applied to peptide and SMILES sequence design, AReUReDi simultaneously optimizes up to five therapeutic properties (including affinity, solubility, hemolysis, half-life, and non-fouling) and outperforms both evolutionary and diffusion-based baselines. These results establish AReUReDi as a powerful, sequence-based framework for multi-property biomolecule generation.
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+ Check out our paper on the [arXiv](https://arxiv.org/abs/2412.17780)!
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+ ## Citation
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+ If you find this repository helpful for your papers and research, please consider citing our paper:
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+ ```python
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+ @article{chen2025areuredi,
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+ title={AReUReDi: Annealed Rectified Updates for Refining Discrete Flows with Multi-Objective Guidance},
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+ author={Tong Chen and Yinuo Zhang and Pranam Chatterjee},
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+ journal={arXiv preprint arXiv:2510.00352},
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+ year={2025}
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+ }
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+ ```